Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide.However, the roles of long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements of the epigenome, remain elusive in the progression of LUAD metastasis.Methods SE-associated lncRNA microarrays were used to identify the dysregulated